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Reporting period – June – September 2021
1. Metabolic profiling of faecal samples from CRGV affected and healthy dogs Faecal samples from dogs with Cutaneous and Renal Glomerular Vasculopathy (CRGV) and healthy dogs have been processed to collect faecal water (the liquid within the faeces). The faecal water may contain information on the metabolites (substances produced as the body makes bigger items into smaller ones) present in the bowel/gut of CRGV affected and healthy dogs. Performing metabolic profiling (identifying the substances) will reveal how much and how many metabolites are present and the differences in the relative amounts of metabolites between healthy and CRGV affected dogs. Unfortunately, due to the ongoing COVID- 19 pandemic, the final 96 samples have not been processed. However, these samples will be processed at the end of September 2021. 2. Detecting the presence of autoantibodies in CRGV affected dogs as a predictor of disease. The groundwork is being laid for the collection of blood from CRGV affected, comparative-CRGV (dogs with kidney disease that isn’t caused by CRGV), and healthy dogs to detect a certain type of antibody called autoantibody anti-neutrophil cytoplasmic, or ANCA for short. An antibody normally helps the body neutralise a foreign invader such as a virus. ANCA actually targets white blood cells that play a role in maintaining health and fighting infection, this targeted attack causes inflammation of small blood vessels. The inflammation seen in ANCA cases is similar to the inflammation seen in CRGV confirmed cases. Therefore, we will be detecting the level of ANCA in CRGV affected dogs which will allow us to determine if ANCA plays a role in the disease process of CRGV. We hope this study will produce the first predictor of canine CRGV, allowing veterinarians to make a rapid diagnosis of CRGV. 3. Further microbial community profiling of the CRGV affected gut. Faecal samples from CRGV and healthy control dogs have been prepared for sequencing (detailed analysis) using an advanced technique (microbial community profiling). This approach will provide information on the bacteria present and the differences between the gut of CRGV affected and healthy dogs. Differences in faecal bacterial amount and type may reveal what organisms could be involved in the disease process of CRGV. This will build upon the previous research mentioned in the December 2020 – May 2021 progress report. In summary, over the past three months the study has:
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“A shortage of sample over the winter and Spring (Alabama rot is a seasonal condition) has necessitated a delay to performing the experiments involved in this project. More samples are expected over the summer; however this means that we won’t have enough samples to justify the study until potentially the end of the year and so we won’t have data until January 2022. In addition, we are sourcing other healthy controls, since further case information later supplied has revealed some of the previous controls were investigated for immune diseases, which may affect ANCA levels. We want to make the study as powerful as possible, so feel this is a prudent move.” – Dr Diane Lee
Unfortunately we have to confirm a further 3 cases of Alabama Rot, also known as CRGV (cutaneous and renal glomerular vasculopathy).
The cases were from Stone (Staffordshire), Oldham and Bolton (G.Manchester). In total, the UK has now seen 277 confirmed cases with 26 cases in 2021. Unfortunately we have to confirm a further 3 cases of Alabama Rot, also known as CRGV (cutaneous and renal glomerular vasculopathy).
The cases were from Bridgend (Rhondda Cynon Taf), Ledbury (Herefordshire) and York (Yorkshire). In total, the UK has now seen 274 confirmed cases with 23 cases in 2021 Unfortunately we have to confirm a further 3 cases of Alabama Rot, also known as CRGV (cutaneous and renal glomerular vasculopathy).
The cases were from Preston (Lancashire), Knaresborough (N.Yorkshire) and Poole (Dorset). In total, the UK has now seen 271 confirmed cases with 20 cases in 2021 Unfortunately we have to confirm a further 5 cases of Alabama Rot, also known as CRGV (cutaneous and renal glomerular vasculopathy).
The cases were from Longwick – 2 cases (Buckinghamshire), Wimbledon and Richmond (G.London) and Reading (Berkshire). In total, the UK has now seen 268 confirmed cases with 17 cases in 2021. Unfortunately we have to confirm a further 9 cases of Alabama Rot, also known as CRGV (cutaneous and renal glomerular vasculopathy).
The cases were from Maidenhead and Reading (Berkshire), Nuthall (Nottinghamshire), York (Yorkshire), two cases from Goring (Oxfordshire), Basingstoke and Alresford (Hampshire), and Beddau (Rhondda Cynon Taff). In total, the UK has now seen 263 confirmed cases with 12 cases in 2021 ARRF are please to announce that we have approved funding for the research project " ANCA link to CRGV" by Dr Diane F. Lee
Please find further details under the 'RESEARCH" tab. Unfortunately, we have to confirm a further three cases of cutaneous renal glomerular vasculopathy (often termed CRGV and sometimes known as Alabama Rot). Dorstone (Herefordshire), Chiswick (G.London), Aylesbeare (Exeter).
This brings the total number of confirmed cases to 254 since 2012, with 3 in 2021. For help recognising some of the signs and to see a map of confirmed cases, please visit www.vets4pets.com/stop-alabama-rot/. |
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